Research Interest
Our research focuses on the development of innovative, sustainable, and efficient synthetic methodologies for modern organic synthesis. The group is particularly interested in electroorganic synthesis, asymmetric synthesis, and methodology development for the selective construction and late-stage functionalization of structurally complex and biologically relevant molecules. We investigate Lewis acid and Brønsted acid catalysis, radical-mediated transformations, C–H functionalization, heterocycle synthesis, and the chemistry of strained-ring systems to enable new bond-forming strategies. In addition, our research extends to the design of functional molecules and materials for targeted drug delivery, integrating synthetic organic chemistry with biomedical applications.
Research Methodology
Research in our group focuses on development of new methodologies for the synthesis of heterocycles as well as carbocycles having novel structural scaffolds. Ring strain in carbocycles as well as in heterocycles make them highly reactive for which strained carbocycles and heterocycles have been employed with various other reactive systems to get precious molecular entities. Synthesis designs are made based on the target structural scaffolds. In this regards the challenge of making all-carbon quaternary center is successfully addressed.These molecular entities can be choosen as precursor for different organic transformations or in total synthesis.
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Asymmetric Synthesis
Getting an enantioenriched molecular scaffold is alwasys of great importance. Keeping that in mind we also involve in asymmetric synthesis of new molecules. The asymmetic version of the developed methodologies are tested employing different mode of chiral induction (using chiral ligand, chiral substrate etc.) or through organocatalysis. At present time we are paying more attention in designing and developing new bifunctional organocatalyst to achieve high enantioselectivity.
Organocatalysis
The use of small organic molecule as catalyst has been known for more than a century. But only in the past decade has organocatalysis bacome a thriving area of general concepts and widely applicable asymmetric reactions.
Electroorganic synthesis
Electroorganic chemistry has emerged as a powerful and sustainable approach for carrying out redox transformations in organic synthesis. By using electricity as a clean reagent, it minimizes the need for hazardous chemical oxidants and reductants, making the process more environmentally friendly. Our research focuses on developing efficient electrochemical methodologies for the synthesis and functionalization of diverse heterocyclic scaffolds and other valuable organic molecules, providing practical and sustainable solutions for modern synthetic chemistry.
Lewis/Brownsted acid catalysis
Lewis and Brønsted acid catalysis provides versatile and efficient strategies for promoting selective organic transformations under mild reaction conditions. Our research focuses on developing catalytic methodologies that enable the construction of structurally complex molecules with high efficiency and selectivity. We are particularly interested in catalyst design, reaction mechanism studies, and the application of acid catalysis to C–C and C–heteroatom bond-forming reactions, heterocycle synthesis, and the synthesis of biologically relevant molecules using sustainable and practical catalytic processes.
Targeted drug delivery
Our research is focused on the design and synthesis of novel drug-like molecules for targeted therapeutic applications. We develop structurally diverse small molecules with potential biological activity using efficient synthetic methodologies. These efforts aim to provide new molecular scaffolds for the development of selective and effective therapeutic agents.
